Chapter 18 : Cancer and Immune System
This activity contains 20 questions.
Which of the following is a cancer of epithelial origin?
Sarcoma
Neoplasm
Lymphoma
Carcinoma
Cancer genes that can cause cancer when they are inactivated is called:
Tumour suppressor genes
None of the above
Proto-oncogenes
Oncogenes
The product of proto-oncogene does not include the following:
Growth factor
Growth factor receptor
Phospholipase
Protein kinase
The translocation of genetic material has been observed in which one of the following cancers:
Philadelphia chromosome
Small cell carcinoma
Li Fraumeni syndrome
Retinoblastoma
Which of the following is not a tumour suppressor gene?
APC
p53
RB
N-myc
The malignant disorder of secondary lymphoid organ is termed as:
Lymphoma
Carcinoma
Sarcoma
Leukemia
Melanoma antigen, a tumour-specific antigen is normally expressed in:
Testis
Brain
Liver
None of the above
Which of the following tumour-associated antigens is lipid in origin?
MART-1
PSA
GM2
p53
Which of the following molecules or cells are most likely to be involved in immunity against tumour?
Megakaryocytes
Macrophages
Eosinophils
NK-cells
Which of the following is not a mechanism of tumour escape?
Metastasis
Generation of B7 negative tumour cells
Antigen masking
Downregulation of class I MHC molecules
Which of the following cytokines show inherent cytotoxic activity toward tumour cells?
IL-2
TGF-β
TNF
γ-IFN
Which of the following factors does not favour tumour growth?
Immunological suppression
Soluble tumor antigen
Metastasis
Cell-mediated immunity
Non-specific immune stimulation of tumour patients results in better humoral and cell immune response. Such non-specific stimulation of immune cells is mediated by:
Mycobacterium tuberculosis
Corynebacterium diphtheria
BCG
Polio virus (attenuated)
The majority of cells that constitute tumour-infiltrating lymphocytes comprise:
Macrophages
NK-cells
T cells
B cells
Which of the following have not been used as an anti-tumour agent?
Fc receptor
LAK cells
Ricin
Diptheria toxin
The transfer of cultured immune cells that have anti-tumour activity into tumour-bearing host is referred to as:
Humoral immunotherapy
Passive immunotherapy
Lymphokine-activated cells
Adoptive cellular immunotherapy
The humoral factor that can be used for providing immunity against some forms of cancer cells is:
Antigen masking
Herceptin
LAK cells
TILs
Viral oncogenes are different from their cellular counterparts in the fact that have:
Intron
Origin of replication
Single exon
Pribnow box
A unique antigen suddenly expressed on a tumour cell could arise from all of the following, except:
Expression of fetal antigen
Immunodeficiency in the host
Mutational event
Viral infection
Carunoembryonic antigen is a type __________ tumour-associated antigen.
Differentiation antigen
Oncofoetal tumour antigen
Mutated protein
Ganglioside antigen
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